Amyotrophic lateral sclerosis (ALS)
نویسندگان
چکیده
منابع مشابه
The National Amyotrophic Lateral Sclerosis (ALS) Registry.
A myotrophic lateral sclerosis (ALS) is a progressive and often fatal neuromuscular disease. Most people die within 2–5 years of being diagnosed with ALS (Mitsumoto, Chad, & Pioro, 1998). Community concerns about perceived clusters of cases of ALS have challenged public health agencies to consider the possible contribution of environmental contaminants to the development of this disease. The ge...
متن کامل[C9orf72 in Japanese amyotrophic lateral sclerosis (ALS)].
Recently, C9orf72 hexanucleotide (GGGGCC) repeat expansion in intron 1 was reported to be the most common cause of sporadic and familial amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD) in the Caucasian population. The frequency of the intronic repeat expansion is up to 21%-57% in familial ALS and 3%-21% in sporadic ALS.In the Japanese population, the C9orf72 repeat expansion w...
متن کاملAmyotrophic Lateral Sclerosis (ALS): Disease Mechanisms
Amyotrophic lateral sclerosis (ALS), known in the United States as Lou Gehrig’s disease, was first described by the famous French scientist and physician Jean-Martin Charcot in 1869. ALS, the most common adult-onset motor neuron disease, refers to a heterogeneous group of neurodegenerative disorders characterized by the selective loss of upper and lower motor neurons (specialized cells that con...
متن کاملMotoneuron firing in amyotrophic lateral sclerosis (ALS)
Amyotrophic lateral sclerosis is an inexorably progressive neurodegenerative disorder involving the classical motor system and the frontal effector brain, causing muscular weakness and atrophy, with variable upper motor neuron signs and often an associated fronto-temporal dementia. The physiological disturbance consequent on the motor system degeneration is beginning to be well understood. In t...
متن کاملThe complex molecular biology of amyotrophic lateral sclerosis (ALS).
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder that causes selective death of motor neurons followed by paralysis and death. A subset of ALS cases is caused by mutations in the gene for Cu, Zn superoxide dismutase (SOD1), which impart a toxic gain of function to this antioxidant enzyme. This neurotoxic property is widely believed to stem from an increased prope...
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ژورنال
عنوان ژورنال: Journal of Physiotherapy
سال: 2013
ISSN: 1836-9553
DOI: 10.1016/s1836-9553(13)70155-3